Psychopharmacology

, Volume 72, Issue 1, pp 17–19

Differential effects of amphetamine and neuroleptics on negative Vs. positive symptoms in schizophrenia

  • B. Angrist
  • J. Rotrosen
  • S. Gershon
Original Investigations

DOI: 10.1007/BF00433802

Cite this article as:
Angrist, B., Rotrosen, J. & Gershon, S. Psychopharmacology (1980) 72: 17. doi:10.1007/BF00433802

Abstract

Positive symptoms of schizophrenia were diminished by neuroleptics and increased by amphetamine and accounted for most of the change seen in the total Brief Psychiatric Rating Scale (BPRS). Negative symptoms in the same subjects were not affected by neuroleptics but increased after amphetamines to a degree that just attained statistical significance. This increase was due to one item (emotional withdrawal) of the negative symptom factor which responded to neuroleptics and amphetamines as did positive symptoms. These findings are discussed with respect to new ideas about the role of dopamine in schizophrenia.

Key words

AmphetamineNeurolepticsDopamineSchizophreniaNegative schizophrenic symptoms

Copyright information

© Springer-Verlag 1980

Authors and Affiliations

  • B. Angrist
    • 1
    • 2
  • J. Rotrosen
    • 1
    • 2
  • S. Gershon
    • 3
  1. 1.Department of PsychiatryNew York University Medical CenterNew YorkUSA
  2. 2.Psychiatry ServiceNew York Veteran's Administration Medical CenterNew YorkUSA
  3. 3.Department of PsychiatryWayne State UniversityDetroitUSA