Psychopharmacology

, Volume 55, Issue 1, pp 103–107

The effect of Δ9, cannabidiol, and cannabinol on the anaesthesia induced by various anaesthetic agents in mice

Authors

  • J. Frizza
    • Department of PharmacologyUniversity of Sydney
  • G. B. Chesher
    • Department of PharmacologyUniversity of Sydney
  • D. M. Jackson
    • Department of PharmacologyUniversity of Sydney
  • R. Malor
    • Department of PharmacologyUniversity of Sydney
  • G. A. Starmer
    • Department of PharmacologyUniversity of Sydney
Original Investigations

DOI: 10.1007/BF00432824

Cite this article as:
Frizza, J., Chesher, G.B., Jackson, D.M. et al. Psychopharmacology (1977) 55: 103. doi:10.1007/BF00432824

Abstract

Δ9-Tetrahydrocannabinol (2.5–80.0 mg/kg) significantly prolonged the anaesthesia induced by ketamine, pentobarbitone, thiopentone, propanidid, and Alfathesin® in a dose-dependent manner. Cannabinol and cannabidiol (both 5.0–80.0 mg/kg) were essentially inactive, except that cannabidiol prolonged pentobarbitone-induced anaesthesia. The interaction of Δ9-tetrahydrocannabinol with the anaesthetic agents was postulated to be due to a centrally mediated action, whereas the effect of cannabidiol on pentobarbitone-induced anaesthesia probably depended on a metabolic interaction. The interaction between the cannabinoids in influencing anaesthesia induced by the above agents was examined, and the interactions were found to be complex.

Key words

AnaesthesiaΔ9-tetrahydrocannabinolCannabinolCannabidiolDrug interactions

Copyright information

© Springer-Verlag 1977