, Volume 87, Issue 3, pp 283–285

Effect of the experimental antidepressant AHR-9377 on performance during differential reinforcement of low response rate

  • James M. O'Donnell
  • Lewis S. Seiden
Original Investigations

DOI: 10.1007/BF00432708

Cite this article as:
O'Donnell, J.M. & Seiden, L.S. Psychopharmacology (1985) 87: 283. doi:10.1007/BF00432708


The effect of acute administration of AHR-9377 on performance under a differential-reinforcement-of-low-rate 72-s (DRL 72-s) schedule was assessed. AHR-9377 reduced response rates and increased reinforcement rates of rats responding under the DRL 72-s schedule; these effects were similar to those of established antidepressant drugs. AHR-9377 also decreased the time of immobility in the forced-swimming test, an empirical model of depression. These results are consistent with the contention that AHR-9377 possesses antidepressant activity.

Key words

AntidepressantsOperant behaviorResponse rateWater reinforcementImmobilitySwimming

Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • James M. O'Donnell
    • 1
  • Lewis S. Seiden
    • 1
  1. 1.Department of Pharmacological and Physiological ScienceThe University of ChicagoChicagoUSA
  2. 2.Life Sciences Division, MS-M881Los Alamos, National LaboratoryLos AlamosUSA