Action of cannabidiol on the anxiety and other effects produced by δ9-THC in normal subjects
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- Zuardi, A.W., Shirakawa, I., Finkelfarb, E. et al. Psychopharmacology (1982) 76: 245. doi:10.1007/BF00432554
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The object of the experiment was to verify whether cannabidiol (CBD) reduces the anxiety provoked by Δ9-TCH in normal volunteers, and whether this effect occurs by a general block of the action of Δ9-TCH or by a specific anxiolytic effect. Appropriate measurements and scales were utilized and the eight volunteers received, the following treatments in a double-blind procedure: 0.5 mg/kg Δ9-TCH, 1 mg/kg CBD, a mixture containing 0.5 mg/kg Δ9-TCH and 1 mg/kg CBD and placebo and diazepam (10 mg) as controls. Each volunteer received the treatments in a different sequence. It was verified that CBD blocks the anxiety provoked by Δ9-TCH, however this effect also extended to marihuanalike effects and to other subjective alterations induced by Δ9-TCH. This antagonism does not appear to be caused by a general block of Δ9-TCH effects, since no change was detected in the pulse-rate measurements. Several further effects were observed typical of CBD and of an opposite nature to those of Δ9-TCH.
These results suggest that the effects of CBD, as opposed to those of Δ9-TCH, might be involved in the antagonism of effects between the two cannabinoids.