Article

Virchows Archiv A

, Volume 373, Issue 3, pp 267-278

Muscle changes in rheumatoid arthritis

A review of the literature with a study of 100 cases
  • éva MagyarAffiliated withDepartment of Pathology, Postgraduate Medical School
  • , A. TalermanAffiliated withDepartment of Pathology and Department of Orthopaedic Surgery, Dr. Daniel den Hoed Kliniek
  • , Judith MohácsyAffiliated with2nd Department of Pathology, Semmelweis Medical School
  • , H. W. WoutersAffiliated withDepartment of Pathology and Department of Orthopaedic Surgery, Dr. Daniel den Hoed Kliniek
  • , W. C. de BruijnAffiliated withDepartment of Pathology, Erasmus University

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Summary

Muscle changes were studied in biopsy material obtained from 100 patients suffering from classical rheumatoid arthritis. The abnormalities consisted of denervation atrophy of type II muscle fibres, degenerative changes in the sarcoplasm including presence of nemaline rods, and changes within the interstitium: namely perivascular nodular myositis, lymphocytic accumulations, different stages of vasculitis and abnormalities within the intramuscular nerves and muscle spindles. The muscles examined were always severely affected. It is considered that the simultaneous presence of these abnormalities is suggestive of rheumatoid arthritis. The importance of histochemical studies is emphasized. The literature concerning muscle changes in rheumatoid arthritis is reviewed.

Key words

Rheumatoid arthritis Muscle changes