Psychopharmacology

, Volume 75, Issue 2, pp 179–183

Effects of pargyline and SKF-525A on brain N,N-dimethyltryptamine concentrations and hyperactivity in mice

  • Alun Morinan
  • Jonathan G. Collier
Original Investigations

DOI: 10.1007/BF00432184

Cite this article as:
Morinan, A. & Collier, J.G. Psychopharmacology (1981) 75: 179. doi:10.1007/BF00432184

Abstract

Mice pretreated with the monoamine oxidase inhibitor pargyline showed a dose-dependent increase in hyperactivity for up to 2 h following injections of N,N-dimethyltryptamine (DMT: 0.5–8.0 mg/kg). Hyperactivity was related to a linear increase in whole brain concentrations of DMT as measured by a new sensitive gas chromatographic assay. The duration of this behaviour paralleled the concentration of DMT in the brain from 15–120 min. However, at 15 min, there was no significant difference in brain DMT concentrations between mice receiving pargyline and those given distilled water at the two dose levels of DMT studied (2.0 and 8.0 mg/kg). Pre-treatment with the microsomal enzyme inhibitor SKF-525A, alone or in combination with pargyline, had no effect on the DMT-induced behaviour or on the brain levels of DMT.

Key words

DMT Gas chromatography Hyperactivity Pargyline SKF-525A Mice 

Copyright information

© Springer-Verlag 1981

Authors and Affiliations

  • Alun Morinan
    • 1
  • Jonathan G. Collier
    • 1
  1. 1.Department of BiochemistryInstitute of PsychiatryLondonEngland
  2. 2.Department of Biological SciencesNorth East Surrey College of TechnologyEwellEngland
  3. 3.Wyeth LaboratoriesMaidenheadEngland

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