Archives of Orthopaedic and Trauma Surgery

, Volume 112, Issue 1, pp 33–35

Ciprofloxacin-impregnated poly-l-lactic acid drug carrier

New aspects of a resorbable drug delivery system in local antimicrobial treatment of bone infections
  • C. Teupe
  • R. Meffert
  • S. Winckler
  • W. Ritzerfeld
  • P. Törmälä
  • E. Brug
Article

DOI: 10.1007/BF00431041

Cite this article as:
Teupe, C., Meffert, R., Winckler, S. et al. Arch Orthop Trauma Surg (1992) 112: 33. doi:10.1007/BF00431041

Summary

Resorbable poly-l-lactic acid (PLLA) cylinders (3.5 mm diameter, 5 mm in length) carrying 6% of weight ciprofloxacin (Ciprobay, Bayer AG, Leverkusen, FRG) were investigated in vitro to explore their properties as a slow-release antibiotic deposit. Forty bioactive cylinders stored in test tubes were covered with phosphate buffer (pH 7.4 at 37°C) and 40 with fresh human blood plasma and tested under various conditions. For comparison a gentamicin-polymethylmethacrylate (PMMA) chain (Septopal, E. Merck, Darmstadt, FRG) was exposed to similar test conditions. The quantities of ciprofloxacin and gentamicin released were analysed by a microbiological method (bioassay). The concentrations of ciprofloxacin released were analysed by a microbiological method (bioassay). The concentrations of ciprofloxacin released from 40 cyclinder were initially very high (up to 180 mg/1) but they decreased rapidly within the first 5 days (4.2–22.5 mg/l). Early release of gentamicin reached up to 227.5 mg/l but dropped to of 22 mg/l on the 14th day. Complete degradation of the PLLA-cylinders was not seen in the observed period of 92 days. The mean loss of mass was 8.4%, The recovery of incorporated ciprofloxacin was 6.5% on average.

Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • C. Teupe
    • 1
  • R. Meffert
    • 1
  • S. Winckler
    • 1
  • W. Ritzerfeld
    • 2
  • P. Törmälä
    • 3
  • E. Brug
    • 1
  1. 1.Klinik und Poliklinik für Unfall- und Handchirurgie der Westfälischen Wilhelms-Universität MünsterGermany
  2. 2.Institut für Medizinische Mikrobiologie der Westfälischen Wilhelms-Universität MünsterGermany
  3. 3.Institute für Plastics TechnologyTechnican University of TampereFinland
  4. 4.Klinik und Poliklinik für Unfall-und Handchirurgie der Westfälischen Wilhelms-Universität MünsterMünsterGermany