Article

Immunogenetics

, Volume 22, Issue 4, pp 309-314

Interaction between des-Tyr1-γ-endorphin and HLA class I molecules: Serological detection of an HLA-A2 subtype

  • Frans H. J. ClaasAffiliated withImmunohaematology and Bloodbank, University Medical Center
  • , Jan J. van der PoelAffiliated withImmunohaematology and Bloodbank, University Medical Center
  • , Ria Castelli-VisserAffiliated withImmunohaematology and Bloodbank, University Medical Center
  • , Jos PoolAffiliated withImmunohaematology and Bloodbank, University Medical Center
  • , Chen RenbiaoAffiliated withShanghai Institute of Immunology, WHO Immunogenetic Collaboration Center
  • , Xu KeyuAffiliated withChinese Academy of Medical Sciences, Institute of Dermatology
  • , Jon J. van RoodAffiliated withImmunohaematology and Bloodbank, University Medical Center

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Abstract

Preincubation of lymphocytes with des-Tyr1-γ-endorphin (DTγE) inhibits the reaction between some HLA alloantisera and their corresponding antigens. One HLA-A2-specific antiserum was found which could detect a subtype of the HLA-A2 antigen on DTγE-treated lymphocytes from some donors. Comparison with the HLA-A2 subtypes as defined by a combination of cytotoxic T lymphocyte typing and biochemistry showed a complete correlation with the previously described HLA-A2.3 subtype.