, Volume 1, Issue 6, pp 482–492

The effects of meprobamate, barbiturates, d-amphetamine and promazine on experimentally induced conflict in the rat


  • Irving Geller
    • Wyeth Institute for Medical Research
  • Joseph Seifter
    • Wyeth Institute for Medical Research
Original Investigations

DOI: 10.1007/BF00429273

Cite this article as:
Geller, I. & Seifter, J. Psychopharmacologia (1960) 1: 482. doi:10.1007/BF00429273


Conflict behavior was induced in rats by simultaneously rewarding with liquid food and punishing with pain shock every lever response made in the presence of a tone. Meprobamate, phenobarbital and pentobarbital increased the number of shocks a rat would accept in order to obtain the food reward; in contrast, promazine and d-amphetamine decreased the number of shocks taken. The technique thus permits a separation on a behavioral basis of meprobamate, pentobarbital and phenobarbital from promazine and d-amphetamine.

Copyright information

© Springer-Verlag 1960