Original Investigations

Psychopharmacologia

, Volume 1, Issue 6, pp 482-492

First online:

The effects of meprobamate, barbiturates, d-amphetamine and promazine on experimentally induced conflict in the rat

  • Irving GellerAffiliated withWyeth Institute for Medical Research
  • , Joseph SeifterAffiliated withWyeth Institute for Medical Research

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Summary

Conflict behavior was induced in rats by simultaneously rewarding with liquid food and punishing with pain shock every lever response made in the presence of a tone. Meprobamate, phenobarbital and pentobarbital increased the number of shocks a rat would accept in order to obtain the food reward; in contrast, promazine and d-amphetamine decreased the number of shocks taken. The technique thus permits a separation on a behavioral basis of meprobamate, pentobarbital and phenobarbital from promazine and d-amphetamine.