Psychopharmacology

, Volume 82, Issue 3, pp 194–198

Serum neuroleptic concentrations and clinical response: A radioreceptor assay investigation of acutely psychotic patients

  • L. T. Kucharski
  • P. Alexander
  • L. Tune
  • J. Coyle
Original Investigations

DOI: 10.1007/BF00427772

Cite this article as:
Kucharski, L.T., Alexander, P., Tune, L. et al. Psychopharmacology (1984) 82: 194. doi:10.1007/BF00427772

Abstract

Twenty-two acutely psychotic patients were rigorously assessed for psychopathology at baseline and after 14 days of neuroleptic treatment. The neuroleptic radioreceptor assay (NRRA) was used to determine serum neuroleptic concentrations. Serum neuroleptic concentration was significantly, nonlinearly related to changes in BPRS Total Score, and BPRS Factor Scores for Thought Disturbance and Anxiety-Depression. Clinical improvement was associated with intermediate (11–50, 51–126 ng/ml haloperidol equivalents) while poor clinical outcome was related to both low (less than or equal to 10 ng/ml) or high (greater than 125 ng/ml) serum levels. The results are discussed in terms of a possible “therapeutic window” for the neuroleptics and the implications this might have for clinical practice.

Key words

Neuroleptics Radioreceptor assay Serum levels Psychosis 

Copyright information

© Springer-Verlag 1984

Authors and Affiliations

  • L. T. Kucharski
    • 1
  • P. Alexander
    • 2
  • L. Tune
    • 3
  • J. Coyle
    • 3
  1. 1.Child Psychiatry M-806Boston University School of MedicineBostonUSA
  2. 2.Department of PsychiatryBrown UniversityProvidenceUSA
  3. 3.Department of Neuroscience, Pharmacology and Experimental Therapeutics and PsychiatryJohns Hopkins University School of MedicineBaltimoreUSA

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