Psychopharmacology

, Volume 81, Issue 4, pp 354–356

Clinical response and plasma haloperidol levels in schizophrenia

  • Michael L. Mavroidis
  • Donald R. Kanter
  • Jack Hirschowitz
  • David L. Garver
Rapid Communications

DOI: 10.1007/BF00427577

Cite this article as:
Mavroidis, M.L., Kanter, D.R., Hirschowitz, J. et al. Psychopharmacology (1983) 81: 354. doi:10.1007/BF00427577

Abstract

Plasma haloperidol levels were compared to clinical response during the first 14 days of drug treatment in 14 DSM III-diagnosed inpatient schizophrenic patients using an improved methodology, which utilized predetermined constant dosages and derived a therapeutic range of plasma haloperidol levels from a curvilinear regression analysis. An inverted U-shaped relationship was found which reflected a significant curvilinear correlation (r=0.66, P<0.02) between plasma levels (as assayed by gas chromatography) and improvement on the Serial New Haven Schizophrenia Index. A therapeutic window was suggested by the present study, with optimum patient response associated with plasma haloperidol levels of 4.2–11.0 ng/ml for the first 2 weeks of treatment.

Key words

SchizophreniaHaloperidolPlasma levelsClinical responseTherapeutic range

Copyright information

© Springer-Verlag 1983

Authors and Affiliations

  • Michael L. Mavroidis
    • 1
    • 2
  • Donald R. Kanter
    • 1
    • 3
  • Jack Hirschowitz
    • 2
    • 4
  • David L. Garver
    • 1
    • 2
    • 5
  1. 1.VA Medical CenterCincinnatiUSA
  2. 2.Department of PsychiatryUniversity of Cincinnati, College of MedicineCincinnatiUSA
  3. 3.Psychology DepartmentUniverity of CincinnatiCincinnatiUSA
  4. 4.University HospitalCincinnatiUSA
  5. 5.Department of Pharmacology and Cell BiophysicsUniversity of CincinnatiCincinnatiUSA
  6. 6.Psychiatry Service (116A)Veterans Administration Medical CenterCincinnatiUSA