Psychopharmacology

, Volume 57, Issue 1, pp 109–114

Antidepressant activity and pharmacological interactions of ciclazindol

Authors

  • Karabi Ghose
    • Medical Research Council Neuropsychiatry LaboratoryWest Park Hospital
  • V. A. Rama Rao
    • Medical Research Council Neuropsychiatry LaboratoryWest Park Hospital
  • J. Balley
    • Medical Research Council Neuropsychiatry LaboratoryWest Park Hospital
  • Alec Coppen
    • Medical Research Council Neuropsychiatry LaboratoryWest Park Hospital
Article

DOI: 10.1007/BF00426966

Cite this article as:
Ghose, K., Rama Rao, V.A., Balley, J. et al. Psychopharmacology (1978) 57: 109. doi:10.1007/BF00426966

Abstract

Ciclazindol, a new tetracyclic compound, appears to be a potentially important antidepressant of the same order as amitriptyline, but with significantly fewer, subjective side effects. Although as a group the patients treated with ciclazidol lost weight, clinical improvement was observed to be significantly corelated with the weight gain in both groups. The peripheral adrenergic interactions were studied. In the dosage used (100 mg/day) ciclazindol was observed to be a peripheral NA-reuptake blocker with no significant effect on the postsynaptic α-receptors.

Plasma concentrations of the drug were estimated and their relationship to the therapeutic outcome, side effects, and adrenergic interaction were studied.

No significant change in resting BP or ECG was observed following 4–6 weeks' treatment with ciclazindol.

Key words

CiclazindolAntidepressant activitySubjective side effectsPeripheral adrenergic interactionsPlasma drug concentration

Copyright information

© Springer-Verlag 1978