Molecular and General Genetics MGG

, Volume 175, Issue 2, pp 145–149

Constitutive mutation of cysJIH operon in a cysB deletion strain of Salmonella typhimurium

Authors

  • Jack Ostrowski
    • Institute of Biochemistry and BiophysicsPolish Academy of Science
  • Danuta Hulanicka
    • Institute of Biochemistry and BiophysicsPolish Academy of Science
Article

DOI: 10.1007/BF00425530

Cite this article as:
Ostrowski, J. & Hulanicka, D. Molec. Gen. Genet. (1979) 175: 145. doi:10.1007/BF00425530

Summary

In a cysB deletion strain a new mutation, denoted cys-2332 was isolated, which causes the constitutive expression of the cysJIH operon. cys-2332 is closely linked to cysJIH and presumably is located in the initiator region of this operon, rendering its expression independent of the cysB gene product and the internal inducer O-acetyl-L-serine. The presence of salfite reductase (encoded by cysI and cysJ) activity in a cysB-cys-2332 double mutant indicates that cysG, which is not linked to cysJIH but is required for the synthesis of the sulfite reductase co-factor siroheme, is not controlled by cysB.

Copyright information

© Springer-Verlag 1979