Human Pharmacology


, Volume 31, Issue 3, pp 265-270

First online:

Gas chromatographic-mass spectrometric isotope dilution determination of N,N-dimethyltryptamine concentrations in normals and psychiatric patients

  • R. J. WyattAffiliated withLaboratory of Clinical Psychopharmacology, Division of Special Mental Health Research, IRP, National Institute of Mental Health, Saint Elizabeths Hospital
  • , L. R. MandelAffiliated withMerck Sharp & Dohme Research Laboratories
  • , H. S. AhnAffiliated withMerck Sharp & Dohme Research Laboratories
  • , R. W. WalkerAffiliated withMerck Sharp & Dohme Research Laboratories
  • , W. J. A. Vanden HeuvelAffiliated withMerck Sharp & Dohme Research Laboratories

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A gas chromatographic-mass spectrometric determination of the plasma N,N-dimethyltryptamine concentration from normals and psychiatric patients revealed that within the limit of sensitivity of the assay (0.5–1.8 ng/ml of plasma), there was no difference amongst normals, patients with psychotic depression, acute and chronic schizophrenia.

Key words

Dimethyltryptamine Hallucinogens Schizophrenia