Psychopharmacology

, Volume 73, Issue 3, pp 286–291

Similarity of the discriminative stimulus effects of ketamine, cyclazocine, and dextrorphan in the pigeon

Authors

  • Seymore Herling
    • Departments of Pharmacology and PsychologyUniversity of Michigan
  • Edward H. CoaleJr.
    • Departments of Pharmacology and PsychologyUniversity of Michigan
  • David W. Hein
    • Departments of Pharmacology and PsychologyUniversity of Michigan
  • Gail Winger
    • Departments of Pharmacology and PsychologyUniversity of Michigan
  • James H. Woods
    • Departments of Pharmacology and PsychologyUniversity of Michigan
Original Investigations

DOI: 10.1007/BF00422419

Cite this article as:
Herling, S., Coale, E.H., Hein, D.W. et al. Psychopharmacology (1981) 73: 286. doi:10.1007/BF00422419

Abstract

Separate groups of pigeons were trained to discriminate the IM injection of ketamine, cyclazocine, or dextrorphan from saline. Each of the training drugs and phencyclidine produced dose-related, drug-appropriate responding in each group of birds. In contrast, ethylketazocine and nalorphine generally produced responding appropriate for saline. These results indicate that common elements of discriminable effects exist among ketamine, cyclazocine, and dextrorphan, structurally dissimilar compounds that are generally considered to belong to distinct pharmacological classes.

Key words

PhencyclidineDrug discriminationKetaminePigeonsDextrorphanEthylketazocineCyclazocineNalorphine
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Copyright information

© Springer-Verlag 1981