Addiction to secobarbital and chlordiazepoxide in the rhesus monkey by means of a self-infusion preference procedure
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.Get Access
Monkeys were exposed to a 24 h continuous experimental procedure which provided a periodic forced choice between the self-infusion of secobarbital versus saline. Preference for secobarbital over saline was readily obtained using choice trials programmed approximately every 2 h at a dose of 9 mg/kg of secobarbital per infusion. Preference for self-infusion of chlordiazepoxide over saline was obtained using choice trials every 3 h, and a dose on the order of 1 mg/kg per infusion. In a subsequent experiment, two of the animals addicted to chlordiazepoxide were given a choice every 3 h between an infusion of chlordiazepoxide or secobarbital. Following a period of intake of both drugs, a gradual shift in preference from chlordiazepoxide to secobarbital was observed over a period of some 60 days. In general, this preference procedure provides a flexible technique with several dependent measures for single or multiple drug addiction studies.
- Bremner, F. J., Cobb, H. W., Hahn, W. C. (1970) The effects of chlordiazepoxide on the behavior of rats in a conflict situation. Psychopharmacologia (Berl.) 17: pp. 275-282
- Davis, J. P., Miller, N. E. (1963) Fear and pain: Their effect on self-injection of amobarbital sodium by rats. Science 141: pp. 1287-1288
- Deneau, G. A. Drug self-administration by monkeys. In: Steinberg, H. eds. (1968) Scientific Basis of Drug Dependence. J. H. Churchill, London
- Deneau, G. A., Yanagita, T., Seevers, M. H. (1965) Psychic dependence studies of self-administration techniques in Rhesus monkeys. Comm. Drug Addiction and Narcotics, NRC-NAS, Houston, Texas
- Findley, J. D., Robinson, W. W. (1971) Aversive preference as a function of fixed-ratio requirements. East. Psychol. Ass., N. Y.
- Findley, J. D., Robinson, W. W., Gilliam, W. (1971) A restraint system for chronic study of the baboon. J. exp. Anal. Behav. 15: pp. 69-71
- Findley, J. D., Robinson, W. W., Gilliam, W., Brady, J. V. (1971) Continuous cardiovascular monitoring in the baboon during long-term behavioral performances. Commun. Behav. Biol. 6: pp. 45-58
- Geller, E., Kulak, S. (1962) Effects of CDP on punished discrimination. Psychopharmacologia (Berl.) 3: pp. 373-385
- Goldberg, S. R., Hoffmeister, F., Schlichting, V., Wuttke, W. (1971) A comparison of pentobarbital and cocaine self-administration in rhesus monkeys: Effects of dose and fixed-ratio parameters. J. Pharmacol. exp. Ther. 179: pp. 277-283
- Perez-Cruet, J., Plumlee, L., Newton, J. E. O. (1964) Chronic basal blood pressure in unanesthetized dogs using the ring-catheter technique. Proc. Symp. Biomed. Engr. 1: pp. 383-386
- Schuster, C. R., Thompson, T. (1963) A technique for studying self-administration of opiates in Rhesus monkeys. Comm. Drug Addication and Narcotics, NRC-NAS, Ann. Arbor, Mich.
- Schuster, C. R., Thompson, T. (1969) Self-administration of and behavioral dependence on drugs. Ann. Rev. Pharmacol. 9: pp. 483-502
- Weeks, J. R.: Fed. Proc. 20 (1961).
- Werdegar, D., Johnson, D. G., Mason, J. W. (1964) A technique for continuous measurements of arterial blood pressure in unanesthetized monkeys. J. appl. Physiol. 19: pp. 519-521
- Yanagita, T., Deneau, G. A., Seevers, M. H. (1963) Methods for studying psychogenic dependence to opiates in the monkey. Comm. Drug Addiction and Narcotics, NRC-NAS, Ann Arbor, Mich.
- Yanagita, T., Takahashi, S. (1970) Development of tolerance to and physical dependence on barbiturates in Rhesus monkeys. J. Pharmacol. exp. Ther. 172: pp. 163-167
- Addiction to secobarbital and chlordiazepoxide in the rhesus monkey by means of a self-infusion preference procedure
Volume 26, Issue 2 , pp 93-114
- Cover Date
- Print ISSN
- Online ISSN
- Additional Links
- Choice Procedure
- Multiple Addiction
- Industry Sectors