, Volume 40, Issue 4, pp 341–350

Extrapyramidal reactions and amine metabolites in cerebrospinal fluid during haloperidol and clozapine treatment of schizophrenic patients


  • J. Gerlach
    • Dept. ESct. Hans Hospital
  • K. Thorsen
    • Dept. ESct. Hans Hospital
  • R. Fog
    • Dept. ESct. Hans Hospital
Short Reports Human Pharmacology

DOI: 10.1007/BF00421473

Cite this article as:
Gerlach, J., Thorsen, K. & Fog, R. Psychopharmacologia (1975) 40: 341. doi:10.1007/BF00421473


8 male schizophrenic patients participated in a double-blind, cross over study of the extrapyramidal side-effects of haloperidol and clozapine (acute dystonia, Parkinsonism and tardive dyskinesia), together with their effect on homo-vanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA) in the cerebrospinal fluid (CSF). Haloperidol (9 mg/day) caused Parkinsonism, reduced tardive dyskinesias and increased the HVA concentration in the CSF. Clozapine (225 mg/day) had no effect on the neurological phenomena but reduced HVA and 5-HIAA concentrations in the CSF. During the discontinuation phase following the administration of haloperidol, tardive dyskinesia occurred or was aggravated; this did not occur after administration of clozapine. Accordingly, it is suggested that clozapine does not induce dopaminergic hypersensibility and, therefore, will not induce tardive dyskinesias.

Key words

ClozapineHaloperidolParkinsonismTardive DyskinesiaHomovanillic AcidDopaminergic Hypersensitivity5-Hydroxyindoleacetic Acid

Copyright information

© Springer-Verlag 1975