Short Reports Human Pharmacology


, Volume 40, Issue 4, pp 341-350

First online:

Extrapyramidal reactions and amine metabolites in cerebrospinal fluid during haloperidol and clozapine treatment of schizophrenic patients

  • J. GerlachAffiliated withDept. E, Sct. Hans Hospital
  • , K. ThorsenAffiliated withDept. E, Sct. Hans Hospital
  • , R. FogAffiliated withDept. E, Sct. Hans Hospital

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8 male schizophrenic patients participated in a double-blind, cross over study of the extrapyramidal side-effects of haloperidol and clozapine (acute dystonia, Parkinsonism and tardive dyskinesia), together with their effect on homo-vanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA) in the cerebrospinal fluid (CSF). Haloperidol (9 mg/day) caused Parkinsonism, reduced tardive dyskinesias and increased the HVA concentration in the CSF. Clozapine (225 mg/day) had no effect on the neurological phenomena but reduced HVA and 5-HIAA concentrations in the CSF. During the discontinuation phase following the administration of haloperidol, tardive dyskinesia occurred or was aggravated; this did not occur after administration of clozapine. Accordingly, it is suggested that clozapine does not induce dopaminergic hypersensibility and, therefore, will not induce tardive dyskinesias.

Key words

Clozapine Haloperidol Parkinsonism Tardive Dyskinesia Homovanillic Acid Dopaminergic Hypersensitivity 5-Hydroxyindoleacetic Acid