Psychopharmacologia

, Volume 46, Issue 2, pp 169–177

Theoretical and methodological considerations on drug discrimination learning

Authors

  • Francis C. Colpaert
    • Department of PharmacologyJanssen Pharmaceutica Research Laboratories
  • Carlos J. E. Niemegeers
    • Department of PharmacologyJanssen Pharmaceutica Research Laboratories
  • Paul A. J. Janssen
    • Department of PharmacologyJanssen Pharmaceutica Research Laboratories
Animal Studies

DOI: 10.1007/BF00421388

Cite this article as:
Colpaert, F.C., Niemegeers, C.J.E. & Janssen, P.A.J. Psychopharmacologia (1976) 46: 169. doi:10.1007/BF00421388
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Abstract

A method is described which allows the assessment of discriminative stimulus properties of drugs, and the ability of amphetamine (0.16 mg/kg, s.c), chlordiazepoxide (5 mg/kg, p.o.), desipramine (5 mg/kg, s.c), and haloperidol (0.02 mg/kg, s.c.) to produce a discriminative stimulus complex (DSC) is evidenced. The method is found to yield clear-cut data that are specifically related to drug discrimination learning without being possibly confounded by state dependent effects. In addition, the experimental procedure is designed so as to provide an appropriate measurement of operant response modulating drug effects.

Key words

Drug discriminationCueState dependent learningAmphetamineDesipramineHaloperidolChlordiazepoxide
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Copyright information

© Springer-Verlag 1976