Molecular Biology Reports

, Volume 11, Issue 3, pp 149–153

The localization of a lectin-like component on the Leishmania cell surface

  • A. G. Hernández
  • N. Rodríguez
  • D. Stojanovic
  • D. Candelle
Article

DOI: 10.1007/BF00419735

Cite this article as:
Hernández, A.G., Rodríguez, N., Stojanovic, D. et al. Mol Biol Rep (1986) 11: 149. doi:10.1007/BF00419735

Abstract

The binding between marcrophage-like cells J774G8 and Leishmania braziliensis (NR) promastigotes was studied ‘in vitro’ by a radioisotopic assay under various conditions in the absence of serum. Different sugars, N-acetyl-D-glucosamine, D-glucose, D-mannose, D-galactose, and chitin, diminished the binding of the parasite, whereas other sugars, D-arabinose, D-fucose and D-xylose, did not affect the binding. The presence of a lectin-like ligand specific for N-acetyl-D-glucosamine has been detected on the cell surface of the Leishmania braziliensis (NR) by fluorescence microscopy.

These data suggest that the binding of the parasite to the host's cell is a ligand-receptor interaction which involves the participation of a lectin-like component on the parasite cell surface.

Copyright information

© Dr W. Junk Publishers 1986

Authors and Affiliations

  • A. G. Hernández
    • 1
  • N. Rodríguez
    • 1
  • D. Stojanovic
    • 1
  • D. Candelle
    • 1
  1. 1.Facultad de CienciasUniversidad Central de VenezuelaCaracasVenezuela

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