Summary
The renal effects of 29'038-Ba, a new long-acting injectable anabolic steroid, have been studied in a group of fifteen elderly subjects with normal or impaired renal function. Renal clearances of inulin and endogenous creatinine, the estimated renal blood flow, and the TmPAH were increased by 16.8, 17.2, 17.9 and 35.3 percent respectively after administration of a total of 400 mg of this compound, in contrast to non-significant changes of CPAH and maximal concentrating capacity. No disturbances of liver function were observed in any of the subjects studied. No general side-effects were noticed except for transiently increased libido, reported by three female subjects in the middle of the treatment-period.
Zusammenfassung
Die Einwirkung von 29'038-Ba, einem neuen langwirkenden injizierbaren anabolen Steroid auf die Nieren, wurde bei einer Gruppe von fünfzehn älteren Patienten mit normaler and beeinträchtigter Nierenfunktion untersucht. Die Nieren-Clearance von Inulin und endogenem Kreatinin, die geschätzte Nierendurchblutung und die TmPAH erhöhten sick um 16,8 bzw. 17,2 bzw. 17,9 bzw. 35,3% nach Verabreichung von insgesamt 400 mg dieses Präparates. Hingegen wurden nur unbedeuteade Veränderungen der CPAH and der maximalen Konzentrationskapazität festgestellt. Irgendwelche Störungen der Leberfunktion konnten bei keinem Patienten beobachtet werden. Auch wurden keine allgemeinen Nebenwirkungen beobachtet, bis auf eine zeitweilig gesteigerte Libido bei drei Patientinnen gegen Mitte der Behandlungszeit.
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Supported in part by Research Grant R/00073 from W. H. O., and by a Grant of the R. Hell. Res. Fndn.
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Dontas, A.S., Papanayiotou, P. & Marketos, S. Renal effects of a new anabolic steroid (29'038-Ba) in old age. Pharmacol. Clin. 1, 43–46 (1968). https://doi.org/10.1007/BF00418703
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DOI: https://doi.org/10.1007/BF00418703