Effect of anticalmodulin drugs on the action of yeast α factor pheromone
- Cite this article as:
- Ruiz, T. & Rodriguez, L. Arch. Microbiol. (1986) 145: 104. doi:10.1007/BF00413035
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Saccharomyces cerevisiae α factor pheromone arrest growth of cells of the a mating type (MAT a) at the G1 phase of the cell cycle. When treatment of MAT a cells with α factor was carried out in the presence of anticalmodulin drugs, trifluoperazine or chlorpromazine, the extent of cell growth arrest induced by α factor was reduced or even became undetectable. These results lend support to the hypothesis that calmodulin plays a role as mediator in the action of α factor on MAT a cells.
Key wordsSaccharomyces cerevisiaeα FactorTrifluoperazineChlorpromazineCalmodulin