Archives of Dermatological Research

, Volume 278, Issue 3, pp 177–183

Anti-oxidant effects of retinoids on inflammatory skin diseases

  • A. Yoshioka
  • Y. Miyachi
  • S. Imamura
  • Y. Niwa
Original Contributions

DOI: 10.1007/BF00412920

Cite this article as:
Yoshioka, A., Miyachi, Y., Imamura, S. et al. Arch Dermatol Res (1986) 278: 177. doi:10.1007/BF00412920

Summary

It is well known that retinoids are effective in the treatment of various dermatological disorders. It has been reported that retinoids have inhibitory effects on the generation of superoxide (O2-) by stimulated polymorphonuclear leukocytes (PMNs). In the present study, we investigated the effects of retinoids on the generation of O2-and other reactive oxygen species (ROS), including OH, H2O2 and chemiluminescence, by zymosan-stimulated PMNs and in the xanthinexanthine oxidase system, because these potent ROS may play an important role in PMN-mediated skin inflammation. It was found that some retinoids had anti-oxidant effects in the PMN system; however, apart from the effect of tretinoin and Ro 10-1670 on OH generation, none of the retinoids studied inhibited ROS generation in the xanthine-xanthine oxidase system. On the basis of these results, we discuss a possible mechanism connected with the role of ROS by which retinoids have favourable effects on several inflammatory skin disorders.

Key words

RetinoidsReactive oxygen speciesPolymorphonuclear leukocytesInflammatory skin diseases

Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • A. Yoshioka
    • 1
  • Y. Miyachi
    • 1
  • S. Imamura
    • 1
  • Y. Niwa
    • 2
  1. 1.Department of Dermatology, Faculty of MedicineKyoto UniversityKyotoJapan
  2. 2.Niwa Institute for ImmunologyKochiJapan