Short Communications

Psychopharmacologia

, Volume 3, Issue 2, pp 132-138

Differential responses based on the physiological consequences of pharmacological agents

  • Jane StewartAffiliated withAyerst Research Laboratories

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Summary

Rats were trained to make differential escape responses based solely on the different physiological states brought about by pharmacological agents. Two groups were trained to differentiate between saline and chlorpromazine while a third group was trained to differentiate between saline and imipramine. When the responses were well established “test drugs” were substituted for the “training drugs” in an attempt to determine the degree of transfer of the learned response from the “training drug” to the “test drug”.

It was found that the chlorpromazine trained response transferred to acepromazine, perphenazine and prothipendyl, whereas there was no transfer from chlorpromazine to prochlorperazine or to imipramine at the doses studied. The imipramine trained response did not transfer to either chlorpromazine or acepromazine. The findings were discussed briefly in terms of the possible features of the physiological states which might be crucial in determining the results.