Journal of Cancer Research and Clinical Oncology

, Volume 100, Issue 1, pp 113–116

Central nervous side effects following ifosfamide monotherapy of advanced renal carcinoma

  • M. E. Heim
  • R. Fiene
  • E. Schick
  • E. Wolpert
  • W. Queißer
Short Communications

DOI: 10.1007/BF00405909

Cite this article as:
Heim, M.E., Fiene, R., Schick, E. et al. J Cancer Res Clin Oncol (1981) 100: 113. doi:10.1007/BF00405909

Summary

Ten patients with advanced renal carcinoma were treated by ifosfamide (50–60 mg/kg/dayx5 days). The treatment was repeated every 4 weeks and continued until progression appeared. Two patients came into partial remission, two had subjective improvement, and six did not respond.

Seven patients developed acute psychopathological symptoms during the first ifosfamide-cycle. Five patients had visual and paranoid hallucinations, four patients were completely confused. Follow-up for up to 10 weeks showed a persisting organic brain syndrome in five patients.

Key words

Renal carcinomaIfosfamideCerebral side effects

Copyright information

© Springer-Verlag 1981

Authors and Affiliations

  • M. E. Heim
    • 1
  • R. Fiene
    • 1
  • E. Schick
    • 1
  • E. Wolpert
    • 1
  • W. Queißer
    • 1
  1. 1.Onkologisches ZentrumFakultät für klinische Medizin Mannheim der Universität HeidelbergMannheimFederal Republic of Germany