, Volume 67, Issue 8, pp 378–383

Metabolic microspheres

Origins and evolution
  • Sidney W. Fox

DOI: 10.1007/BF00405480

Cite this article as:
Fox, S.W. Naturwissenschaften (1980) 67: 378. doi:10.1007/BF00405480


A systematic review of catalytic activities in thermal proteinoids and microspheres aggregated therefrom yields some new inferences on the origins and evolution of metabolism. Experiments suggest that, instead of being inert, protocells were already biochemically and cytophysically competent. The emergence and refinement of metabolism ab initio is thus partly traced conceptually. When the principle of molecular self-instruction, as of amino acids in peptide synthesis, is taken into account as a concomitant of natural selection, an expanded theory of organismic evolution, including saltations, emerges.

Copyright information

© Springer-Verlag 1980

Authors and Affiliations

  • Sidney W. Fox
    • 1
  1. 1.Institute for Molecular and Cellular EvolutionUniversity of MiamiCoral Gables