Psychopharmacologia

, Volume 16, Issue 1, pp 30–48

Self-administration of psychoactive substances by the monkey

A measure of psychological dependence
  • Gerald Deneau
  • Tomoji Yanagita
  • M. H. Seevers
Original Investigations

DOI: 10.1007/BF00405254

Cite this article as:
Deneau, G., Yanagita, T. & Seevers, M.H. Psychopharmacologia (1969) 16: 30. doi:10.1007/BF00405254

Summary

A method has been developed which permits monkeys to self-administer drug solutions, at will, through indwelling intravenous catheters. Psychological dependence on the effects of a drug occurs when a naive monkey voluntarily initiates and maintains self-administration of the drug. If, in addition to psychological dependence, the drug also produces psychotoxicity, either directly or upon abrupt withdrawal, it has a potential abuse liability.

In the present study monkeys developed psychological dependence on morphine, codeine, cocaine, d-amphetamine, pentobarbital, ethanol, and caffeine. All of these drugs except caffeine produced psychotoxicity. Monkeys did not develop psychological dependence on nalorphine, morphine-nalorphine mixtures, chlorpromazine, mescaline or physiological saline.

Key-Wards

Psychological Dependence Psychotoxicity Drug Abuse Drug Dependence Psychoactive Drugs 

Copyright information

© Springer-Verlag 1969

Authors and Affiliations

  • Gerald Deneau
    • 1
  • Tomoji Yanagita
    • 1
  • M. H. Seevers
    • 1
  1. 1.Department of PharmacologyThe University of Michigan Medical SchoolAnn Arbor
  2. 2.Southern Research InstituteBirmingham
  3. 3.Central Institute for Experimental AnimalsKawasakiJapan

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