, Volume 34, Issue 5, pp 362–365

Prevention or delay of Type 1 (insulin-dependent) diabetes mellitus in children using nicotinamide

  • R. B. Elliott
  • H. P. Chase

DOI: 10.1007/BF00405010

Cite this article as:
Elliott, R.B. & Chase, H.P. Diabetologia (1991) 34: 362. doi:10.1007/BF00405010


A controlled trial of oral nicotinamide to prevent the onset of diabetes mellitus in high risk children was conducted in two centres. The selection criteria were age less than 16 years, islet cell antibody ≥80 IUs, and first phase insulin release < 5th percentile. All of eight untreated control subjects have developed diabetes, whereas only 1 of 14 treated children has diabetes to date. This data suggests that nicotinamide has an effect in preventing Type 1 (insulin-dependent) diabetes and that randomized controlled studies are now indicated.

Key words

Nicotinamide Type 1 (insulin-dependent diabetes mellitus pre-Type 1 diabetes islet-cell antibody intravenous glucose tolerance test 

Copyright information

© Springer-Verlag 1991

Authors and Affiliations

  • R. B. Elliott
    • 1
  • H. P. Chase
    • 2
  1. 1.Department of PaediatricsSchool of MedicineAucklandNew Zealand
  2. 2.Barbara Davis Center for Childhood Diabetes, Department of PaediatricsUniversity of Colorado Health Sciences CenterDenverUSA