Psychiatric diagnosis and a typology of clinical drug effects
- Donald F. Klein
- … show all 1 hide
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.Get Access
Analyses of clinical drug effects have largely been derived from univariate rating scale or global improvement scale data. In general, global improvement scales have proved more sensitive and clinically useful than univariate scales. Another approach, presented here, is to use qualitative outcome categories to which patients are assigned on the basis of the configuration of multiple changes. Such a systematic qualitative outcome typology is presented as used in an experimental study of 309 non-chronic voluntary psychiatric patients who, regardless of symptomatology or diagnosis, were randomly assigned to placebo, imipramine or chlorpromazine-procyclidine, in a fixed dosage double-blind study.
This outcome typology is compared with a global improvement scale and related to diagnosis. In general, the drug outcome categorization was equal or superior to the global improvement scale in detecting the differences between drugs and placebo. Furthermore, by utilizing the author's diagnostic schema, as well as the qualitative outcome typology, the prediction of specific drug induced qualitative outcomes by diagnosis was demonstrated.
- Fink, M., M. Pollack, D. F. Klein, A. G. Blumberg, I. Belmont, J. C. Kramer, and A. Willner: Comparative studies of chlorpromazine and imipramine. I: Drug discriminating patterns. Neuropsychopharmacol. 3, 370–372 (1964).
- Klein, D. F.: Delineation of two drug responsive anxiety syndromes. Psychopharmacologia (Berl.) 5, 397–408 (1964).
- —: Behavioral effects of imipramine and phenothiazines: Implications for a psychiatric pathogenetic theory and theory of drug action. Rec. Advanc. Biol. Psychol. 7, 273–287 (1965).
- —: The importance of psychiatric diagnosis in the prediction of clinical drug effects. Arch. gen. Psychiat. 16, 118–126 (1967a).
- —: Diagnosis and pattern of reaction to drug treatment: Clinically derived formulations. The Role and Methodology of Classification in Psychiatry and Psychopathology. M. M. Katz, J. O. Cole and W. Barton (eds.). Washington, D. C.: Government Printing Office (1967b).
- —, and M. Fink: Behavioral reaction patterns with phenothiazines. Arch. gen. Psychiat. 7, 449–459 (1962a).
- — —: Psychiatric reaction patterns to imipramine. Amer. J. Psychiat. 119, 432 to 438 (1962b).
- Levenstein, S., D. F. Klein, and M. Pollack: Follow-up study of formerly hospitalized voluntary psychiatric patients: The first two years. Amer. J. Psychiat. 122, 1102–1109 (1966).
- Pollack, M., S. Levenstein, and D. F. Klein: A three year posthospital followup of adolescent and adult schizophrenics. Amer. J. Orthopsychiat. 38, 94–109 (1968).
- Psychiatric diagnosis and a typology of clinical drug effects
Volume 13, Issue 5 , pp 359-386
- Cover Date
- Print ISSN
- Online ISSN
- Additional Links
- Drug Therapy
- Multivariate Analysis
- Improvement Measures
- Industry Sectors
- Donald F. Klein (1)
- Author Affiliations
- 1. Hillside Hospital, Glen Oaks, N.Y.