Animal Studies

Psychopharmacologia

, Volume 20, Issue 2, pp 169-171

First online:

Exploratory behavior in chronic disulfoton poisoning in mice

  • George ClarkAffiliated withDepartment of Anatomy, Medical University of South CarolinaVeterans Administration HospitalDepartment of Human Ecology, School of Health, University of OklahomaRohrer, Hibler and Replogle
  • , Anna G. KoesterAffiliated withDepartment of Anatomy, Medical University of South CarolinaVeterans Administration HospitalDepartment of Human Ecology, School of Health, University of OklahomaRohrer, Hibler and Replogle
  • , David W. PearsonAffiliated withDepartment of Anatomy, Medical University of South CarolinaVeterans Administration HospitalDepartment of Human Ecology, School of Health, University of OklahomaRohrer, Hibler and Replogle

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Abstract

The behavior of four groups of white mice was compared using the “hole-board” test. One male and one female group were chronically poisoned with disulfoton while similar untreated male and female groups served as controls. The scores of the poisoned animals were significantly higher than those of the controls, indicating that the poisoned animals exhibited increased exploratory behavior. There were no sex differences.

Key-Words

Exploratory Behavior Disulfoton Acetylcholinesterase Sex