A simple and reliable conflict procedure for testing anti-anxiety agents
Original Investigations Animal Studies
Received: 29 October 1970 Revised: 04 February 1971 DOI:
Cite this article as: Vogel, J.R., Beer, B. & Clody, D.E. Psychopharmacologia (1971) 21: 1. doi:10.1007/BF00403989 Abstract
The effects of three benzodiazepines (chlordiazepoxide, diazepam, and oxazepam), meprobamate, pentobarbital,
d-amphetamine sulfate, magnesium pemoline, and scopolamine hydrobromide were studied with a simple conflict procedure in which thirsty naive rats were periodically administered shocks for licking water. The results indicated that this simple procedure clearly demonstrated “anti-anxiety” (i.e., increases in punished responding) effects with benzodiazepines, meprobamate and pentobarbital. Doses of d-amphetamine sulfate, magnesium pemoline, and scopolamine hydrobromide did not increase responding. Key-Words Benzodiazepines Minor Tranquilizers Conflict Anti-Anxiety Psychopharmacological Procedures References
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