Psychopharmacologia

, Volume 21, Issue 1, pp 1–7

A simple and reliable conflict procedure for testing anti-anxiety agents

Authors

  • John R. Vogel
    • The Squibb Institute for Medical Research
  • Bernard Beer
    • The Squibb Institute for Medical Research
  • Donald E. Clody
    • The Squibb Institute for Medical Research
Original Investigations Animal Studies

DOI: 10.1007/BF00403989

Cite this article as:
Vogel, J.R., Beer, B. & Clody, D.E. Psychopharmacologia (1971) 21: 1. doi:10.1007/BF00403989

Abstract

The effects of three benzodiazepines (chlordiazepoxide, diazepam, and oxazepam), meprobamate, pentobarbital, d-amphetamine sulfate, magnesium pemoline, and scopolamine hydrobromide were studied with a simple conflict procedure in which thirsty naive rats were periodically administered shocks for licking water. The results indicated that this simple procedure clearly demonstrated “anti-anxiety” (i.e., increases in punished responding) effects with benzodiazepines, meprobamate and pentobarbital. Doses of d-amphetamine sulfate, magnesium pemoline, and scopolamine hydrobromide did not increase responding.

Key-Words

BenzodiazepinesMinor TranquilizersConflictAnti-AnxietyPsychopharmacological Procedures

Copyright information

© Springer-Verlag 1971