, Volume 20, Issue 4, pp 307–314

Rubidium chloride ingestion by volunteer subjects: Initial experience


  • Ronald R. Fieve
    • N.Y. State Psychiatric Institute
  • Herbert L. Meltzer
    • N.Y. State Psychiatric Institute
  • Reginald M. Taylor
    • N.Y. State Psychiatric Institute
Original Investigations Human Pharmacology

DOI: 10.1007/BF00403562

Cite this article as:
Fieve, R.R., Meltzer, H.L. & Taylor, R.M. Psychopharmacologia (1971) 20: 307. doi:10.1007/BF00403562


The authors report on the first metabolically controlled study of rubidium chloride administered to humans. Four subjects were given doses of 8.2–12.4 meq. RbCl in a single day, and biological half lives calculated from urinary excretion ranged from 21–55 days. A long term study of chronic rubidium loading in one of these subjects demonstrated no undesirable clinical side effects. After ingestion of a total dose of 268 meq. within a period of 75 days a plasma level of 0.16 meq./liter rubidium was obtained. Urinary excretion proceeded at a rate consistent with a 50 day half life.

The authors speculate on the potential usefulness of RbCl for modification of behavior and affect.


Rubidium ChlorideHuman IngestionMetabolismBehaviorElectrolyte

Copyright information

© Springer-Verlag 1971