Different aetiologies of Type 2 (non-insulin-dependent) diabetes mellitus in obese and non-obese subjects
- Cite this article as:
- Arner, P., Pollare, T. & Lithell, H. Diabetologia (1991) 34: 483. doi:10.1007/BF00403284
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Insulin responses to intravenous glucose infusion and glucose utilization during hyperinsulinaemic euglycaemic clamp were determined in a large homogeneous group of 65-year-old male subjects. Twenty-eight had untreated Type 2 (non-insulin-dependent) diabetes mellitus and the remaining 44 control subjects had a normal glucose tolerance. Diabetic patients with abdominal obesity displayed peripheral insulin resistance in combination with defective insulin secretion, whereas non-obese diabetic patients showed only a secretory defect. Thus, Type 2 diabetes in obese and non-obese elderly male subjects may take two forms where the cause of hyperglycaemia differs.