Environmental Monitoring and Assessment

, Volume 22, Issue 1, pp 57–72

Effects of Cu2+, Pb2+ and Zn2+ on voltage-activated currents in Helix pomatia L. Neurons

  • O. N. Osipenko
  • T. Kiss
  • J. Salánki
Article

DOI: 10.1007/BF00402655

Cite this article as:
Osipenko, O.N., Kiss, T. & Salánki, J. Environ Monit Assess (1992) 22: 57. doi:10.1007/BF00402655

Abstract

Effects of Cu2+, Pb2+ and Zn2+ were studied on voltage-activated Na-, Ca-, and K-currents in snail neurons. It was found that: 1. In normal physiological saline Cu2+, Pb2+ and Zn2+ ions exerted complex changes on the total ionic currents; 2. All three metal ion have depressed the inward Na-currents but with different KD, moreover Pb2+ increased Na-current at low concentrations (5 μM); 3. The inward Ca-current was also reduced. The sequence of the blocking effect of metals was different: Pb>Cu>Zn, however the steady-state inactivation was influenced only by Cu2+; 4. Outward currents were decreased in all neurons by Cu2+, but the effects of Pb2+ and Zn2+ were either depression or enhancement in different indentified neurons; 5. The possibility of binding heavy metals to wide variety of membrane proteins and the observed effects on different ionic channels suggest that the metal effect is complex and cannot be taken as a specific one to a single channel type or site of location.

Copyright information

© Kluwer Academic Publishers 1992

Authors and Affiliations

  • O. N. Osipenko
    • 1
  • T. Kiss
    • 1
  • J. Salánki
    • 1
  1. 1.Balaton Limnological Research Institute of the Hungarian Academy of SciencesTihanyHungary
  2. 2.Department of General Physiology of Nervous System of the A. A. Bogomoletz Institute of PhysiologyUkrainian Academy of SciencesKievU.S.S.R.