, Volume 19, Issue 2, pp 199–203

Retarded depression and the dopamine metabolism

  • H. M. van Praag
  • J. Korf
Letters to the Editors Human Pharmacology

DOI: 10.1007/BF00402643

Cite this article as:
van Praag, H.M. & Korf, J. Psychopharmacologia (1971) 19: 199. doi:10.1007/BF00402643


It was demonstrated that the influence of i.v. administered probenecid on HVA concentration in CSF was less pronounced in a group of retarded depression than in a group of non-retarded depression and a non-depressive control group. The figures corresponded to that found in Parkinson patients.

These findings suggest a decreased consumption of dopamine in the brain in retarded depression. This might be understood as an indication that, disorders of cerebral dopamine metabolism are related not so much to a specific nosological entity as to a given motor status, possibly that of hypokinesia.


Dopamine Metabolism Probenecid Depression Hypokinesia Parkinson's Disease 

Copyright information

© Springer-Verlag 1971

Authors and Affiliations

  • H. M. van Praag
    • 1
  • J. Korf
    • 1
  1. 1.Department of Biological Psychiatry, Psychiatric University ClinicState University of GroningenThe Netherlands

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