Retarded depression and the dopamine metabolism
- Cite this article as:
- van Praag, H.M. & Korf, J. Psychopharmacologia (1971) 19: 199. doi:10.1007/BF00402643
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It was demonstrated that the influence of i.v. administered probenecid on HVA concentration in CSF was less pronounced in a group of retarded depression than in a group of non-retarded depression and a non-depressive control group. The figures corresponded to that found in Parkinson patients.
These findings suggest a decreased consumption of dopamine in the brain in retarded depression. This might be understood as an indication that, disorders of cerebral dopamine metabolism are related not so much to a specific nosological entity as to a given motor status, possibly that of hypokinesia.