, Volume 19, Issue 2, pp 153–162

A double-blind comparison of dothiepin and amitriptyline for the treatment of depression with anxiety

  • M. S. Lipsedge
  • W. Linford Rees
  • D. J. Pike
Human Pharmacology

DOI: 10.1007/BF00402639

Cite this article as:
Lipsedge, M.S., Rees, W.L. & Pike, D.J. Psychopharmacologia (1971) 19: 153. doi:10.1007/BF00402639


Fifty out-patients took part in a double-blind controlled comparison of two antidepressants dothiepin and amitriptyline. The subjects' psychiatric state was assessed by both self-rating and clinician-rated scales. Patients were followed up for a period of about three months.

The results of the trial showed that dothiepin was superior to amitriptyline at the 5% significance level in terms of its antidepressant activity. Dothiepin was better tolerated in relation to its side effects than amitriptyline. For relief of anxiety symptoms both drugs appeared equally effective.


Antidepressant Dothiepin Trial 

Copyright information

© Springer-Verlag 1971

Authors and Affiliations

  • M. S. Lipsedge
    • 1
  • W. Linford Rees
    • 1
  • D. J. Pike
    • 2
  1. 1.Department of Psychological MedicineSt. Bartholomew's HospitalLondon, E. C. 1
  2. 2.Department of Applied StatisticsReading UniversityUSA

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