State-dependent learning produced by depressant and atropine-like drugs
- Dr. Donald A. Overton
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Rats were trained to escape from shock in a T maze. In this situation a variety of drugs were tested and compared with regard to their ability to produce state-dependent, or dissociated, learning. Three major results were obtained. First, several depressant drugs produced a state in which learning was partially dissociated from learning which occurred in the nondrug state. Pentobarbital, phenobarbital, alcohol, urethane, and meprobamate were approximately equivalent in their actions and were interchangeable. Second, atropine produced a drug state in which learning was partially dissociated from learning in the nondrug state and from learning which occurred under the depressant drugs. The effects of atropine which produced this state neither mimicked nor antagonized those effects of the depressant drugs which allowed them to dissociate learning. This result is especially important as it indicates that not all dissociation phenomena are the result of some single unidimensional process (eg., activation level changes produced by the drugs). Third, many drugs which dissociate learning in other experimental situations have weak or nonexistent dissociative effects on escape learning in the T maze. The present technique appears to be useful for directly comparing the dissociative effects of a variety of drugs.
- Arduini, A., and M. G. Arduini: Effects of drugs and metabolic alterations on brain stem arousal mechanism. J. Pharmacol. exp. Ther. 110, 76–85 (1954).
- Barry, H., E. Koepfer, and J. Lutch: Learning to descriminate between alcohol and nondrug condition. Psychol. Rep. 16, 1072 (1965).
- Belleville, R. E.: Control of behavior by drug-produced internal stimuli. Psychopharmacologia (Berl.) 5, 95–105 (1964).
- Bindra, D., K. Nyman, and J. Wise: Barbiturate-induced dissociation of acquisition and extinction: role of movement-initiating processes. J. comp. physiol. Psychol. 60, 223–228 (1965).
- Cahen, R. L., and K. Tvede: Homatropine methylbromide; a pharmacological reevaluation. J. Pharmacol. exp. Ther. 105, 166–177 (1952).
- Carlton, P. L., and J. R. Vogel: Studies of the amnesic properties of scopolamine. Psychon. Sci. 3, 261–262 (1965).
- Case, T. J., and W. H. Funderbunk: An effect of curare on the central nervous system. Trans. Amer. neurol. Ass. 72, 195–196 (1947).
- Cheek, D. B.: Unconscious perception of meaningful sounds during surgical anesthesia as revealed under hypnosis. Amer. J. clin. Hypnosis 1, 101–113 (1958).
- Conger, J. J.: The effect of alcohol on conflict behavior in the albino rat. Quart. J. Stud. Alcohol. 12, 1–29 (1951).
- French, J. D., M. Verzeano, and H. W. Magoun: A neural basis of the anesthetic state. Arch. Neurol. Psychiat. (Chic.) 69, 519–529 (1953).
- Gardner, L., and C. McCullough: A reinvestigation of the dissociative effect of curariform drugs. Amer. Psychologist. 17, 398 (abstract) (1962).
- Girden, E.: Generalized conditioned responses under curare and erythroidine. J. exp. Psychol. 31, 105–119 (1942).
- —, and E. A. Culler: Conditioned responses in curarized striate muscle in dogs. J. comp. Psychol. 23, 261–274 (1937).
- Grossman, S. P., and N. E. Miller: Control for stimulus-change in the evaluation of alcohol and chlorpromazine as fear-reducing drugs. Psychopharmacologia (Berl.) 2, 342–351 (1961).
- Heistad, G. T., and A. A. Torres: A mechanism for the effect of a tranquilizing drug on learned emotional responses. Univ. Minn. med. Bull. 30, 518–527 (1959).
- Holmgren, B.: Conditioned avoidance reflex under pentobarbital. Bol. Inst. Estud. méd. biol. (Mex.) 22, 21–38 (1964)
- Karczmar, A. G., and J. P. Long: Relationship between peripheral cholinolytic potency and tetraethylpyrophosphate antagonism of a series of atropine substitutes. J. Pharmacol. exp. Ther. 123, 230–237 (1958).
- King, E. E.: Differential action of anesthetic and multineuronal blocking agents upon EEG arousal and recruitment responses evoked from the brain stem. Fed. Proc. 13, 375 (1954).
- Kletzkin, M., and K. Swan: The effects of meprobamate and pentobarbital upon cortical and subcortical responses to auditory stimulation. J. Pharmacol. exp. Ther. 125, 35–39 (1959).
- Martin, W. R., V. G. Vernier, and K. R. Unna: Effects of dilantin and phenobarbital on the response of the cortex to stimulation of the activating center. J. Pharmacol. exp. Ther. 110, 35–36 (1954).
- Meyers, F. H., and B. E. Abreu: A comparison of the central and peripheral effects of atropine, scopolamine and some synthetic atropine-like compounds. J. Pharmacol. exp. Ther. 104, 387–395 (1952).
- Otis, L. S.: Dissociation and recovery of a response learned under the influence of chlorpromazine or saline. Science 143, 1347–1348 (1964).
- Overton, D. A.: Control of learned responses by drug states. Doctoral dissertation, McGill Univ. 1962.
- —: State-dependent or “dissociated” learning produced with pentobarbital. J. comp. physiol. Psychol. 57, 3–12 (1964).
- Paskal, V.: Dissociative effects of atropine on a simple learned task in the rat. Undergraduate research reports in psychology, McGill Univ., p. 37–43 (1962).
- Rinaldi, F., and H. E. Himwich: Cholinergic mechanism involved in function of mesodiencephalic activating system. Arch. Neurol. Psychiat. (Chic.) 73, 396–402 (1955).
- Sachs, E.: The role of brain electrolytes in learning and retention. Unpublished doctoral dissertation, Univ. of Rochester 1962.
- —, M. Weingarten, and N. W. Klein jr.: Effects of chlordiazepoxide on the acquisition of avoidance learning and its transfer to the normal state and to other drug conditions. Psychopharmacologia (Berl.) 9, 17–30 (1966).
- Stein, L.: Anticholinergic drugs and the central control of thirst. Science 139, 46–48 (1963).
- Stevens, J. R., G. H. Glaser, and P. MacLean: The influence of sodium amytal on the recollection of seizure states. Trans. Amer. neurol. Ass. 40–45 (1954).
- Stewart, J.: Diiferential responses based on the physiological consequences of pharmacological agents. Psychopharmacologia (Berl.) 3, 132–138 (1962).
- Zapata-Ortiz, V., R. C. de la Mata, and A. Campos-Iturrizaga: The effect of bemegride (megimide) and metrazol on some neurodepressors. J. Pharmacol. exp. Ther. 125, 347–352 (1959).
- State-dependent learning produced by depressant and atropine-like drugs
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- Dr. Donald A. Overton (1) (2)
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- 1. Department of Psychiatry, Albert Einstein College of Medicine, 10461, New York City
- 2. Department of Psychiatry, Eastern Pennsylvania Psychiatric Inst., 3300 Henry Ave., 19129, Philadelphia, Penna., USA