, Volume 12, Issue 2, pp 158-163

Self-administration of d-amphetamine by rats

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Self-administration of d-amphetamine by rats was characterized by periods of drug intake and abstinence. Frequency of responding for drug injection was found to vary inversely as a function of drug dose per infusion (magnitude of reinforcement), and directly as a function of number of responses required per infusion (fixed-ratio reinforcement schedule). In several regards, reinforcement by d-amphetamine resembled that produced by electrical stimulation of the brain.

This research was supported in part by grants MH-08565, MH-11135, and MH-14112 from U.S.P.H.S. to the University of Minnesota.