, Volume 13, Issue 3, pp 222-257

Comprehensive observational assessment: Ia. A systematic, quantitative procedure for assessing the behavioral and physiologic state of the mouse

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A systematic observational method is described for comprehensively assessing and quantifying the behavioral and physiologic state of the mouse and its response to drugs. With this method, the pattern profile of various classes of pharmacologic agents and their members can be identified and differentiated, and the relative specificity of their actions defined. The method is applicable to a wide range of investigative goals. Inter- and intra-observer reliability studies have shown it to meet the pragmatic requirements for research.

The procedure was developed initially at Schering Corp., Bloomfield, N. J. Its further development and revision was supported by grant No. MH 10990 of the National Institutes of Mental Health.