, Volume 13, Issue 3, pp 222–257

Comprehensive observational assessment: Ia. A systematic, quantitative procedure for assessing the behavioral and physiologic state of the mouse

  • Samuel Irwin
Original Investigations

DOI: 10.1007/BF00401402

Cite this article as:
Irwin, S. Psychopharmacologia (1968) 13: 222. doi:10.1007/BF00401402


A systematic observational method is described for comprehensively assessing and quantifying the behavioral and physiologic state of the mouse and its response to drugs. With this method, the pattern profile of various classes of pharmacologic agents and their members can be identified and differentiated, and the relative specificity of their actions defined. The method is applicable to a wide range of investigative goals. Inter- and intra-observer reliability studies have shown it to meet the pragmatic requirements for research.


Mouse Animal Behavior Observational Measurement Drugs Biological Assay 

Copyright information

© Springer-Verlag 1968

Authors and Affiliations

  • Samuel Irwin
    • 1
    • 2
  1. 1.Department of PsychiatryUniversity of Oregon Medical SchoolPortland
  2. 2.Oregon Regional Primate Research Center Beaverton