Immunogenetics

, Volume 18, Issue 1, pp 79–89

Structural analysis of insulin determinants seen by T cells directed by H-2 genes

Authors

  • Janet Talmon
    • Department of Cell BiologyThe Weizmann Institute of Science
  • Graziella Ranghino
    • Department of Structural ChemistryThe Weizmann Institute of Science
  • Ada Yonath
    • Department of Structural ChemistryThe Weizmann Institute of Science
  • Irun R. Cohen
    • Department of Cell BiologyThe Weizmann Institute of Science
Article

DOI: 10.1007/BF00401358

Cite this article as:
Talmon, J., Ranghino, G., Yonath, A. et al. Immunogenetics (1983) 18: 79. doi:10.1007/BF00401358

Abstract

The magnitude of the immune response of lymphocytes to defined antigenic determinants of ungulate insulins is controlled by the products of H-2 genes. Based on the crystallographically solved structure of porcine insulin, the close homology of all the ungulate insulins, and the amino acid substitutions, we built models of the different insulins. We analyzed the likely conformations of the antigenic determinants, and proposed structural specificities accounting for the immunologic phenomena observed.

Copyright information

© Springer-Verlag 1983