Article

Immunogenetics

, Volume 18, Issue 1, pp 79-89

First online:

Structural analysis of insulin determinants seen by T cells directed by H-2 genes

  • Janet TalmonAffiliated withDepartment of Cell Biology, The Weizmann Institute of Science
  • , Graziella RanghinoAffiliated withDepartment of Structural Chemistry, The Weizmann Institute of Science
  • , Ada YonathAffiliated withDepartment of Structural Chemistry, The Weizmann Institute of Science
  • , Irun R. CohenAffiliated withDepartment of Cell Biology, The Weizmann Institute of Science

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Abstract

The magnitude of the immune response of lymphocytes to defined antigenic determinants of ungulate insulins is controlled by the products of H-2 genes. Based on the crystallographically solved structure of porcine insulin, the close homology of all the ungulate insulins, and the amino acid substitutions, we built models of the different insulins. We analyzed the likely conformations of the antigenic determinants, and proposed structural specificities accounting for the immunologic phenomena observed.