Human Genetics

, Volume 73, Issue 3, pp 225–229

Direct regional assignment of the gene for vitamin D binding protein (Gc-globulin) to human chromosome 4q11-q13 and identification of an associated DNA polymorphism

Authors

  • Nancy E. Cooke
    • Department of MedicineUniversity of Pennsylvania
    • Department of Human GeneticsUniversity of Pennsylvania
  • H. F. Willard
    • Department of Medical GeneticsUniversity of Toronto
  • E. V. David
    • Department of MedicineUniversity of Pennsylvania
    • Department of Human GeneticsUniversity of Pennsylvania
  • Donna L. George
    • Department of Human GeneticsUniversity of Pennsylvania
    • Howard Hughes Medical InstituteUniversity of Pennsylvania
Original Investigations

DOI: 10.1007/BF00401232

Cite this article as:
Cooke, N.E., Willard, H.F., David, E.V. et al. Hum Genet (1986) 73: 225. doi:10.1007/BF00401232

Summary

Using a characterized human vitamin D binding protein (DBP) cDNA probe and a panel of rodent X human somatic cell hybrids, we established the chromosomal location of the structural gene for DBP on human chromosome 4. In situ hybridization of 3H-labeled DBP cDNA to human metaphase chromosomes confirmed this assignment and allowed regional localization to bands 4q11–4q13. A restriction fragment length polymorphism associated with the DBP gene that should prove useful in future linkage studies was identified with the enzyme BamHI.

Copyright information

© Springer-Verlag 1986