Original Papers Clinical Oncology or Epidemiology

Journal of Cancer Research and Clinical Oncology

, Volume 95, Issue 2, pp 187-196

Spontaneous endocrine tumors in Sprague-Dawley rats

  • H. SuzukiAffiliated withAbteilung für Experimentelle Pathologie, Medizinische Hochschule Hannover
  • , U. MohrAffiliated withAbteilung für Experimentelle Pathologie, Medizinische Hochschule Hannover
  • , G. KimmerleAffiliated withInstitut für Toxikologie, Bayer AG

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Summary

Spontaneous endocrine tumors were found in 81 of 100 Sprague-Dawley rats (42 males and 39 females) which survived for more than 2 years. Most of these tumors were medullary carcinomas of the thyroid, followed by tumors of the anterior pituitary gland, pheochromocytomas and cortical adenomas of the adrenal gland, and islet cell tumors of the pancreas. Multiple occurrence of these tumors was frequently observed. This study describes the morphology of these spontaneous endocrine tumors.

Key words

Spontaneous endocrine tumors Sprague-Dawley rats Multiple endocrine tumors