Journal of Cancer Research and Clinical Oncology

, Volume 95, Issue 2, pp 187–196

Spontaneous endocrine tumors in Sprague-Dawley rats


  • H. Suzuki
    • Abteilung für Experimentelle PathologieMedizinische Hochschule Hannover
  • U. Mohr
    • Abteilung für Experimentelle PathologieMedizinische Hochschule Hannover
  • G. Kimmerle
    • Institut für ToxikologieBayer AG
Original Papers Clinical Oncology or Epidemiology

DOI: 10.1007/BF00401012

Cite this article as:
Suzuki, H., Mohr, U. & Kimmerle, G. J. Cancer Res. Clin. Oncol. (1979) 95: 187. doi:10.1007/BF00401012


Spontaneous endocrine tumors were found in 81 of 100 Sprague-Dawley rats (42 males and 39 females) which survived for more than 2 years. Most of these tumors were medullary carcinomas of the thyroid, followed by tumors of the anterior pituitary gland, pheochromocytomas and cortical adenomas of the adrenal gland, and islet cell tumors of the pancreas. Multiple occurrence of these tumors was frequently observed. This study describes the morphology of these spontaneous endocrine tumors.

Key words

Spontaneous endocrine tumorsSprague-Dawley ratsMultiple endocrine tumors

Copyright information

© Springer-Verlag 1979