, Volume 95, Issue 2, pp 187-196

Spontaneous endocrine tumors in Sprague-Dawley rats

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access

Summary

Spontaneous endocrine tumors were found in 81 of 100 Sprague-Dawley rats (42 males and 39 females) which survived for more than 2 years. Most of these tumors were medullary carcinomas of the thyroid, followed by tumors of the anterior pituitary gland, pheochromocytomas and cortical adenomas of the adrenal gland, and islet cell tumors of the pancreas. Multiple occurrence of these tumors was frequently observed. This study describes the morphology of these spontaneous endocrine tumors.

This work was supported by Alexander von Humboldt-Foundation