, Volume 37, Issue 2 Supplement, pp S82-S89

On the pathogenesis of IDDM

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A model of the pathogenesis of insulin-dependent diabetes mellitus, i.e. the initial phase of beta-cell destruction, is proposed: in a cascade-like fashion efficient antigen presentation, unbalanced cytokine, secretion and poor beta-cell defence result in beta-cell destruction by toxic free radicals (O2 and nitric oxide) produced by the beta cells themselves. This entire process is under polygenetic control.