Diabetologia

, Volume 37, Supplement 2, pp S82–S89

On the pathogenesis of IDDM

Authors

  • J. Nerup
    • Steno Diabetes Center
  • T. Mandrap-Poulsen
    • Steno Diabetes Center
  • S. Helqvist
    • Steno Diabetes Center
  • H. U. Andersen
    • Steno Diabetes Center
  • F. Pociot
    • Steno Diabetes Center
  • J. I. Reimers
    • Steno Diabetes Center
  • B. G. Cuartero
    • Steno Diabetes Center
  • A. E. Karlsen
    • Steno Diabetes Center
  • U. Bjerre
    • Steno Diabetes Center
  • T. Lorenzen
    • Steno Diabetes Center
Article

DOI: 10.1007/BF00400830

Cite this article as:
Nerup, J., Mandrap-Poulsen, T., Helqvist, S. et al. Diabetologia (1994) 37: S82. doi:10.1007/BF00400830

Summary

A model of the pathogenesis of insulin-dependent diabetes mellitus, i.e. the initial phase of beta-cell destruction, is proposed: in a cascade-like fashion efficient antigen presentation, unbalanced cytokine, secretion and poor beta-cell defence result in beta-cell destruction by toxic free radicals (O2 and nitric oxide) produced by the beta cells themselves. This entire process is under polygenetic control.

Key words

Insulin-dependent diabetes mellitusfree radicalscytokinesbeta-cell destruction

Abbreviations

IDDM

Insulin-dependent diabetes mellitus

TNF

tumour necrosis factor

IL-1

interleukin-1

BB

bio-breeding

NOD

non-obese diabetic

IFN

interferon

APC

antigen presenting cells

mn SOD

manganosuperoxide dismutase

NO

nitric oxide

NOS

nitric oxide synthases

ONOO

peroxynitrite

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Copyright information

© Springer-Verlag 1994