Review

Diabetologia

, Volume 39, Issue 4, pp 375-382

First online:

Maternally inherited diabetes and deafness: a new diabetes subtype

  • J. A. MaassenAffiliated withDepartment of Medical Biochemistry, Sylvius Laboratory, Leiden University
  • , T. KadowakiAffiliated withThird Department of Internal Medicine, Faculty of Medicine, University of Tokyo

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Summary

Diabetes mellitus is a common disease with many forms of clinical expression. In addition, the development of diabetic complications is not only dependent on glycaemic control but also on individual factors which may be related to genetic heterogeneity. At present, multiple genetic factors are being recognized as contributing to the development of diabetes or possibly modulating its clinical expression. The purpose of this review is to give an overview of our current knowledge on a subtype of diabetes which is apparently caused by a single mutation in the mitochondrial DNA.

Keywords

Genetics maternally inherited diabetes and deafness NIDDM IDDM mitochondria MELAS syndrome