Diabetologia

, Volume 39, Issue 9, pp 1005–1029

The role of interleukin-1 in the pathogenesis of IDDM

  • T. Mandrup-Poulsen
Review

DOI: 10.1007/BF00400649

Cite this article as:
Mandrup-Poulsen, T. Diabetologia (1996) 39: 1005. doi:10.1007/BF00400649

Abbreviations

AA

Arachidonic acid

AcP

associated peptide

APC

antigen presenting cell

BB

BioBreeding

DAG

diacylglycerol

FACS

flourescence activated cell sorter

GTP

guanosine triphosphate

HLA

human leukocyte antigen

HSP

heat shock protein

ICAM

intercellular adhesion molecule

ICE

interleukin-1 converting enzyme

iCOX

inducible cyclooxygenase

IFN

interferon

IL

interleukin

IL-1Ra

IL-1 receptor antagonist

IL-1RT

IL-1 receptor type

LFA

lymphocyte function associated

LPS

lipopolysaccharide

MAPK

mitogen activated protein kinase

MHC

major histocompatibility complex

NK

natural killer

NO

nitric oxide

NOD

non-obese diabetic

PARP

poly(ADP)ribose polymerase

PBMNC

peripheral blood mononuclear cells

PGE2

prostaglandin E2

PHA

phytohaemagglutinin

PKC

protein kinase C

PLA

phospholipase A

PLAP

phospholipase A activating protein

PLC

phospholipase C

PPD

purified protein derivative of tuberculin

scid

severe combined immunodeficiency

SMnase

sphingomyelinase

SOD

Superoxide dismutase

Tc

T-cytotoxic

Th

T-helper

TNF

tumour necrosis factor

Copyright information

© Springer-Verlag 1996

Authors and Affiliations

  • T. Mandrup-Poulsen
    • 1
  1. 1.Steno Diabetes CenterGentofteDenmark