Diabetologia

, Volume 38, Issue 3, pp 337–343

Failure of glucagon suppression contributes to postprandial hyperglycaemia in IDDM

  • S. Dinneen
  • A. Alzaid
  • D. Turk
  • R. Rizza
Originals

DOI: 10.1007/BF00400639

Cite this article as:
Dinneen, S., Alzaid, A., Turk, D. et al. Diabetologia (1995) 38: 337. doi:10.1007/BF00400639

Summary

Carbohydrate ingestion results in a fall in glucagon concentration in non-diabetic but not in diabetic individuals. To determine if, and the mechanism by which, lack of postprandial suppression of glucagon contributes to hyperglycaemia, nine subjects with insulin-dependent diabetes mellitus (IDDM) ingested 50 g of glucose containing both [2-3H] glucose and [6-3H] glucose on two occasions. [6-14C] glucose, insulin and low-dose somatostatin were infused intravenously at the same rates on both occasions. A basal glucagon infusion was started either at the same time (“constant glucagon”) or 2 h following (“suppressed glucagon”) glucose ingestion. This resulted in lower (p<0.001) glucagon concentrations during the first 2 h of the suppressed than during the constant glucagon study days (63±1 vs 108±2 pg/ ml). Lack of suppression of glucagon led to higher (p<0.01) postprandial glucose concentrations (10.3±0.9 vs 8.1±0.7 mmol/l) and a greater (p<0.02) integrated glycaemic response. The excessive rise in glucose was due to higher (p<0.02) rates of postprandial hepatic glucose release during the constant than during the suppressed glucagon study days, whether measured using either [6-3H] glucose (2.6±0.2 vs 2.0±0.2 mmol·kg−1 per 6 h) or [2-3H] glucose (3.0±0.3 vs 2.4±0.2 mmol·kg−1 per 6 h) as the meal tracer. Glucose disappearance, initial splanchnic glucose clearance and hepatic glucose cycling did not differ on the two occasions. Thus, the present studies demonstrate that lack of postprandial suppression of glucagon, by increasing hepatic glucose release, contributes to hyperglycaemia in subjects with IDDM.

Key words

Hepatic glucose release hepatic glucose cycling glucose/glucose 6-phosphate cycling insulin-dependent diabetes mellitus 

Abbreviations

IDDM

Insulin-dependent diabetes mellitus

Copyright information

© Springer-Verlag 1995

Authors and Affiliations

  • S. Dinneen
    • 1
  • A. Alzaid
    • 1
  • D. Turk
    • 1
  • R. Rizza
    • 1
  1. 1.Endocrine Research Unit, Department of MedicineMayo ClinicRochesterUSA