Journal of Cancer Research and Clinical Oncology

, Volume 114, Issue 6, pp 579–582

Aqueous extract of betel-nut of North-East India induces DNA-strand breaks and enhances rate of cell proliferation in vitro

Effects of betel-nut extract in vitro
  • K. K. Wary
  • R. N. Sharan
Original Papers Experimental Oncology

DOI: 10.1007/BF00398180

Cite this article as:
Wary, K.K. & Sharan, R.N. J Cancer Res Clin Oncol (1988) 114: 579. doi:10.1007/BF00398180


An aqueous extract of betel-nut has been found to be able to induce strand breaks in DNA of mouse kidney cells in vitro. It has been also found to be able to enhance the rate of cell division at a dose of 100 μg/ml while a higher dose of 250 μg/ml was extremely toxic to the cells. Compared with arecoline (10 μg/ml), the aqueous extract of betel-nut seems to be a more potent carcinogen to mouse kidney cells in vitro.

Key words

Betel-nutDNA-strand breaksCarcinogenesisIn vitro

Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • K. K. Wary
    • 1
  • R. N. Sharan
    • 1
  1. 1.Radiation and Molecular Biology Unit, Department of Biochemistry, School of Life SciencesNorth-Eastern Hill UniversityShillongIndia
  2. 2.Institut für MedizinKFAJülichFRG