, Volume 5, Issue 3, pp 221-225

Nucleotide sequence of the cytochrome B gene and adjacent regions from rat liver mitochondrial DNA

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The nucleotide sequence of a 1.76 Kbp segment from rat liver mitochondrial DNA has been determined. It contains the gene for the cytochrome b apoprotein and the tRNA genes for threonine, glutamic acid, and proline. The arrangement of these genes in rat liver mitochondria is the same as in human (Anderson et al. 1981) or mouse (Bibb et al. 1981) mitochondria. The comparison of the cytochrome b sequences so far determined, reveals that several regions in these proteins are highly conserved.

Abbreviations: Cyt b, cytochrome b apoprotein; U.R.F., unidentified reading frame (Anderson et al. 1981). Other abbreviations follow IUB-IUPAC conventions