Journal of Cancer Research and Clinical Oncology

, Volume 113, Issue 1, pp 51–55

Inhibition of liver metastasis in mice by blocking hepatocyte lectins with arabinogalactan infusions and d-galactose

  • J. Beuth
  • H. L. Ko
  • K. Oette
  • G. Pulverer
  • K. Roszkowski
  • G. Uhlenbruck
Original Papers Experimental Oncology

DOI: 10.1007/BF00389966

Cite this article as:
Beuth, J., Ko, H.L., Oette, K. et al. J Cancer Res Clin Oncol (1987) 113: 51. doi:10.1007/BF00389966

Summary

According to our hypothesis, organ-specific lectins (e.g., the d-galactose-specific hepatic binding protein) play an important role in the organ location of metastatic malignant cells. The rapid clearance and uptake by the liver of tritiated α-acid-(asialo)glycoprotein from the circulation of Balb/c mice was markedly delayed after preinjection of d-galactose or arabinogalactan. The preinjection (1h) and regular application (for 3 days after tumor cell inoculation in Balb/c mice) of the receptor blocking agents d-galactose and arabinogalactan prevented the settling of sarcoma L-1 tumor in the liver completely, but did not influence the settling in the lung. Other galactans, dextrans, and phosphate-buffered saline showed no effect. Therefore, when lectins were blocked with competitive-specific glycoconjugates, colonization was prevented.

Key words

Liver metastasis Lectins Arabinogalactan d-Galactose 

Copyright information

© Springer-Verlag 1987

Authors and Affiliations

  • J. Beuth
    • 1
  • H. L. Ko
    • 1
  • K. Oette
    • 2
  • G. Pulverer
    • 1
  • K. Roszkowski
    • 1
  • G. Uhlenbruck
    • 3
  1. 1.Institute of HygieneUniversity of CologneCologne 41Federal Republic of Germany
  2. 2.Department of Clinical ChemistryUniversity Clinics of CologneCologne 41Federal Republic of Germany
  3. 3.Department of ImmunobiologyMedical University Clinic ICologne 41Federal Republic of Germany