Zeitschrift für Parasitenkunde

, Volume 49, Issue 2, pp 133–137

Delayed type hypersensitivity in guinea pigs infected subcutaneously with Naegleria fowleri Carter

  • Peter Diffley
  • Michael R. Skeels
  • Franklin Sogandares-Bernal
Article

DOI: 10.1007/BF00382420

Cite this article as:
Diffley, P., Skeels, M.R. & Sogandares-Bernal, F. Z. F. Parasitenkunde (1976) 49: 133. doi:10.1007/BF00382420

Summary

A soluble fraction, derived from Naegleria fowleri trophozoites disrupted by freeze-thawing, was tested for antigenic properties. Intradermal injections of this preparation were administered to guinea pigs previously infected subcutaneously with viable N. fowleri. Delayed hypersensitivity to the antigen and loss of weight, the diagnostic symptom of visceral naegleriasis, were observed in the surviving animals. Fifty percent of the guinea pigs, however, did not lose weight and had a reduced reaction to the antigen. The apparent differences in the immunocompetence of guinea pigs inoculated subcutaneously and intranasally with N. fowleri are compared.

Copyright information

© Springer-Verlag 1976

Authors and Affiliations

  • Peter Diffley
    • 1
  • Michael R. Skeels
    • 1
  • Franklin Sogandares-Bernal
    • 1
    • 2
  1. 1.Department of ZoologyUniversity of MontanaUSA
  2. 2.Department of BiologySouthern Methodist UniversityDallasUSA
  3. 3.Department of Zoology, Morrill Science CenterUniversity of MassachusettsAmherstU.S.A.