Pflügers Archiv

, Volume 422, Issue 5, pp 472–475

Prolonged exercise reduces Ca2+ release in rat skeletal muscle sarcoplasmic reticulum

  • Terence G. Favero
  • Isaac N. Pessah
  • Gary A. Klug
Heart, Circulation, Respiration and Blood; Environmental and Exercise Physiology

DOI: 10.1007/BF00375074

Cite this article as:
Favero, T.G., Pessah, I.N. & Klug, G.A. Pflugers Arch. (1993) 422: 472. doi:10.1007/BF00375074

Abstract

Prolonged exercise decreased the rate of Ca+ release in sarcoplasmic reticulum (SR) vesicles isolated from rat muscle by 20–30% when release was initiated by 5, 10, and 20 μM AgNO3. [3H]Ryanodine binding was also depressed by 20% in SR vesicles isolated from the exercised animals. In contrast, the maximum amount of Ca2+ released by Ag+ remained unaffected by exercise. The passive permeability of SR vesicles and the rate of Ca2+ release in the presence of ruthenium red, a known inhibitor of the Ca2+ release mechanism, was not affected by prolonged exercise. These results suggest that exercise depressed Ca2+ release from SR by directly modifying the Ca2+ release channel.

Key words

Exercise Sarcoplasmic reticulum Ca2+ release 

Copyright information

© Springer-Verlag 1993

Authors and Affiliations

  • Terence G. Favero
    • 1
  • Isaac N. Pessah
    • 2
  • Gary A. Klug
    • 1
  1. 1.Department of Exercise and Movement Science and Institute of NeuroscienceUniversity of OregonEugeneUSA
  2. 2.Department of Pharmacology and Toxicology, School of Veterinary MedicineUniversity of CaliforniaDavisUSA